2019年5月29日，来自加拿大约克大学拉森德工程学院机械工程系Pouya Rezai副教授访问微纳电子学系，并在理科一号楼1131会议室做了题为《Manipulation, separation and assay of microparticles and organisms using microfluidics》的学术报告。我校微纳电子学系、生物医学工程系以及清华大学相关领域的老师以及研究生、本科生参加了报告会，并与报告人进行了热烈的讨论。
Manipulation, separation and assay of microparticles and organisms using microfluidics
Almost everything that you can imagine is either a multiphase fluid or interacts with a fluid. Health related examples include circulating tumor cells in blood. infectious microorganisms in food, and rare invading toxicants and heavy metals in water. Many cells and model organisms of disease that are used for research reside in fluidic environments. Detection and monitoring of these analytes are of high interest in biomedical engineering research. The fields of medical diagnostics, water monitoring, food inspection, and environmental testing are all experiencing paradigm shifts with the evolution of related MEMS and microfluidic biosensors. Excellent detection sensitivity and specificity has been achieved but only in ideal lab environments with highly controlled synthetic samples. A major bottleneck and challenge in transferring these biosensors from the lab to the point-of-care or the point-of-need is to deal with the issues associated with on-site preparation and processing of complex and real multi-phase fluidic samples.
Our lab is interested in the fundamental science and engineering of multiphase fluids from sorting and separation of microorganisms in Newtonian and non-Newtonian fluids, to manipulation, chemical exposure and neurobehavioral screening of small-scale model organisms of neurodegenerative diseases. A common denominator in all these applications is to understand how micro-scale objects of various properties and sizes interact with each other and their fluidic environment physically, chemically and biologically. In my talk, I will provide you with some basic concepts of microparticles hydrodynamics in microfluidic channels, exploiting the advantages of channel design and passive and active forces to achieve sorting and separation of particles based on their size and inherent properties. I will also show some applications of our research in (1) separation of bacteria in water and viscoelastic fluids and (2) manipulation of small-scale organisms such as C. elegans, D. melanogaster, and D. rerio in Lab-on-a-Chip electro-fluidic devices to study Parkinson’s disease at early stages of development.
I am thankful to the organizers of this event and extremely keen to see many colleagues and friends at Peking University who are interested in establishing research and education partnerships with me and the Department of Mechanical Engineering at York University. We always welcome collaborations with experts in all areas of science such as biology, bioinformatics, chemistry and materials as well as with MEMS, microfluidic and bioelectronic experts.